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Immunol Cell Biol 80:550557 Kim SM, Ha JS, Han AR, Cho SW, Yang SJ (2019) Effects of -lipoic acid on LPS-induced neuroinflammation and NLRP3 inflammasome activation through the regulation of BV-2 microglial cells activation

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4.1 Risks of supplement use during chemotherapy The use of natural remedies during chemotherapy in breast cancer is a compound scenario that includes the safety issue as well as drugsupplement interferences and merits meticulous assessment, because these interventionsusually considered as harmless substancesmay significantly alter the pharmacokinetic/pharmacodynamic response, antitumoural activity, and toxicity profile to conventional oncologic treatment (200)