In addition to the Mediterranean diet, healthy elders with oral CoQ 10 supplementation showed significant benefits in their redox-state parameters, postprandial metabolism of advanced glycation end products (AGEs), metabolomic profiles, and the modulation of gene expressions that involved anti-inflammatory, endoplasmic reticulum stress, DNA repair, and antioxidant functions [94,95,96,97,98,99]
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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 60% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof
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