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De novo methods include design and analysis (computational and experimental approaches to create and optimize peptide sequences) and synthesis (chemical and biological methods to construct these peptides) techniques

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1 The discovery of vascular receptors that control vessel tone and neurohumoral mediators in hypertension has led to the development of modern antihypertensive drugs such as beta-blockers, angiotensin converting enzyme inhibitors, AT-1 receptor blockers or calcium channel blockers

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