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One possible mechanism which could link both vitamin B 12 and folate with depressive and psychotic disorders relates to their role in the one-carbon metabolism, which is implicated in diverse processes including DNA methylation, epigenetic control of gene expression, DNA synthesis, membrane signaling, maintenance of cellular redox homeostasis and detoxification capacity [54]
doi: 10.1021/acs.analchem.7b03144
Researchers often evaluate safety profiles, biological responses, and tolerability data as part of broader investigations