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Activated AMPK can initiate autophagy indirectly by inactivating mTORC1 or directly by phosphorylating ULK1 ( Autophagy regulation by both mTORC1 and AMPK is, however, generally very unspecific and only responds to certain nutrient conditions such as glucose or amino acid starvation ( 1.1.2 Nucleation The nucleation phase of autophagy has proven to be exceedingly complicated and hard to study, which is why it is still not fully understood

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The regulatory apoptotic activity of p53 [227] is significantly increased in response to hypoxic conditions within villous trophoblasts [230232] and signifies a greater degree of apoptosis secondary to hypoxia-reoxygenation [233] than from hypoxia alone [230]