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Mechanistically, the peptide perturbs the FOXO4 interaction with p53, which selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis (Baar et al., 2017)

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Dopaminergic neurons in the substantia nigra pars compacta release dopamine, which binds to D1 receptors in the direct pathway to excite motor-promoting signals and to D2 receptors in the indirect pathway to suppress inhibitory signals [3,4]

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If youre relaxed in both mind and body, well-nourished and hydrated, and havent been working out that muscle, youre likely to experience less pain