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Agents that cause depletion of catecholamines from the sympathetic nerve terminals (e.g., reserpine) can also antagonize indirectly acting agents (such as tyramine) because there is a lack of catecholamines to be released

Early Response Phase (Months 2-3) What to expect: Noticeable improvement in energy and motivation Better exercise recovery Possible initial changes in body composition Continued improvement in sleep Lab monitoring: First follow-up IGF-1 testing at 8-12 weeks