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Whether pharmacological TREK-1 blockade (which is partial and reversible, unlike genetic knockout) carries seizure risk at therapeutic doses is unknown

Priority research needs include large-scale randomized controlled trials to establish efficacy and safety, dose-ranging studies to optimize treatment protocols, long-term safety studies particularly regarding cancer risk, and comparative effectiveness research with established therapies

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(2003) Intravenous administration of vitamin B12 in the treatment of hyperhomocysteinemia associated with end-stage renal disease

[DOI] [PubMed] [Google Scholar] 36

Together, these three peptides create a compounding effect that addresses skin aging, damage, and inflammation simultaneously