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Conclusion Both the central circadian clock system and the control center of the GH/IGF-1 axis are located in the hypothalamus and related genes/hormones are expressed/released in circadian rhythm, which regulate metabolism through multi-level interactions

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It attenuates ischemia/reperfusion injury by suppressing NLRP3 inflammasome and apoptosis, mitigating ferroptosis via Nur77-IDH1 signaling (Zhang et al., 2020