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Impairments to the BBB disrupt the brain's microenvironment homeostasis, ultimately resulting in neuronal injury and functional anomalies, a phenomenon extensively documented in neurodegenerative disease studies [1]

in the case of PKA-mediated phosphorylation and desensitization, low nanomolar concentrations of agonist are sufficient to phosphorylate and desensitize the 2-AR, due to the amplification of the response through cyclic AMP generation and PKA activation

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MAIN FUNCTION OF CREATINE The main function of creatine is to regenerate adenosine triphosphate (ATP)

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