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Since levothyroxine requires an acidic gastric environment for optimal dissolution and absorption, and its absorption can be affected by the rate of gastric emptying, patients may experience variations in thyroid hormone levels when starting semaglutide therapy

There is also variable contribution from T-helper type 1 (Th1) driven pathways, including interferon-gamma (IFN-) and interleukin 12 (IL-12), as well as T-helper type 17 (Th17) and T-helper type 22 (Th22) cells [25]

Occasional missed doses have minimal impact on overall outcomes

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