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Clinical validation remains limited because large-scale human trials and regulatory approval are not established

doi: 10.1017/S0033291700037417 21 EdwardsJCMcGrathSBaldwinALivingstoneMKewleyA

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Strikingly, both class I GRXs became oxidized even in freshly prepared GSH buffer, with most of the protein species containing either an intramolecular disulfide or being glutathionylated

We believe that this mechanism may explain the increased ROS levels observed in cells exposed to V-9302 (Fig