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Unexplained hypercobalaminemia, particularly levels above 1,000 pg/mL, has been associated with liver disease, kidney dysfunction, myeloproliferative disorders, and certain solid cancers in multiple large-scale studies

Previous Gastric Surgery: Procedures like gastric bypass can reduce the stomach's ability to produce intrinsic factor and absorb B12

What is Vitamin B12 good for

We are seeing more cases of vitamin B12 deficiencies, even in men and women who adhere to healthy eating and lifestyles

No published time-course demonstrates diminishing effect, and mechanistic reviews note the absence of receptor desensitization that would predict tolerance