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26 This dualistic behavior reflects the complexity and context-dependence of autophagy in cardiac physiology

Bourgis et al., 1999

Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT

The SURMOUNT-1 Phase 3 trial published in the New England Journal of Medicine demonstrated 20.9% mean body weight reduction at 72 weeks on tirzepatide 15mg weekly versus 3.1% with placebo

Interestingly, adoptive cell transfer with T cells lacking the Nox prevented ATII-induced increase in vascular ROS production and blood pressure in this animal model

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