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NNMT is upregulated in the white adipose tissue of obese animals and humans, and its activity is mechanistically linked to depleted cellular NAD+ and SAM pools

As a modified C-terminal fragment of human growth hormone (hGH fragment 177-191), this peptide is highly sought after in metabolic and lipolytic research models

NNMT methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor

Lv, X.-C., Guo, W.-L., Li, L., Yu, X.-D

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Ongoing studies explore its influence on cellular communication pathways associated with nutrient utilization, energy balance, and metabolic adaptation