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They occur naturally in the body and play roles in signaling, regulation, repair, immune response, hormone modulation, and more

3.1 Changes in sleep with aging Sleep serves a restorative role, allowing the brain and body to recover from the oxidative and metabolic demands of wakefulness

Although free radical reactions are necessary for the defense mechanism of cells such as neutrophils and macrophages from immune system cells, overproduction of free radicals results in tissue damage and cell death [3]

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