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Woo-Suk Lee et al conducted adipose-derived mesenchymal stem cell injections in 24 patients with knee OA, resulting in significant improvement in WOMAC scores and no adverse events observed

(2011) Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis, Nat

Treatment consists of replacement of kidney tubular losses, symptomatic management of systemic complications, and specific therapy directed at the basic defect, i.e., lysosomal cystine accumulation

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Mild and temporary side effects were reported

Aged C57BL/6J mice (18-24 months) : more naturalistic model, slow but robust, ideal for long-term studies on Semax or Selank