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The variable R group gives rise to the four most commonly known cobalamins: cyanocobalamin (CNCbl), methylcobalamin (MeCbl), adenosylcobalamin (AdCbl, also known as cobamamide or 5-deoxyadenosylcobalamin), and hydroxocobalamin (OHCbl)

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This dual-mechanism strategy enables researchers to explore the synergistic amplification of GH secretion, providing a powerful model for examining neuroendocrine regulation, metabolic processes, and tissue adaptation