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In some embodiments, a composition disclosed herein is administered on or near the round window or the crista fenestrae cochleae through entry via a post-auricular incision and surgical manipulation into or near the round window or the crista fenestrae cochleae area

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( c ) Cyclin E1 and IDH1 immunoblot in cells transduced with shRNAs targeting IDH1 (shIDH1)

Furthermore, laboratory experiments have found it enhances melatonin production in the pineal gland, crucial for regulating sleep cycles, thereby contributing to improved sleep quality, cognitive function and overall well-being (2)

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Cancer Cell 2012;22:631-44