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What the Evidence Does NOT Show Because the marketing around these compounds is expansive, it is worth stating explicitly what the published record does not establish: It does not show that cagrilintide is superior, equal, or inferior to tirzepatide no head-to-head trial exists, so any ranking is cross-trial inference

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Factors such as chronotype, comorbidities, sex-specific differences, light exposure patterns, frailty status, and polypharmacy can significantly influence circadian responsiveness and metabolic outcomes

A careful assessment in the office is important to tailor an effective treatment plan

They also do not screen out every possible driver of insomnia