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and bioorthogonal conjugation of immunomodulators to the EcN surface, where dissolution of an enteric coating in the intestine exposes the conjugates to drive macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2, complementing the probiotic's intrinsic effects (Peng et al., 2024)

BL-804, a peptidic CXCR4 antagonist, induces leukemia cell death and specific leukemia cell mobilization in relapsed/refractory acute myeloid leukemia patients in an ongiong phase IIa clinical trial

By supplementing with vitamin B12 alongside semaglutide, women can experience a noticeable boost in energy levels, combating fatigue and lethargy often associated with weight loss efforts

Therefore, we may identify novel strategies for immunotherapeutic intervention in autoinflammatory diseases and their accompanying associated disorders by thoroughly understanding the mechanisms inherent to urate-induced dysregulation of immune cells and disease advancement

Proc Natl Acad Sci U S A 116(22):1102811037

doi: 10.1111/nyas.13021