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The trade-off is twice as many injections and slightly more complex scheduling

Under unstressed conditions, Nrf2 is rapidly turned over in the cytosol via ubiquitin-dependent degradation mediated by Keap1 [3537]

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A distinct tissue-repair cluster shared this profile but also upregulated genes involved in the remodeling of extracellular matrix ( Fbln2 , Col6a2 , Adamts1 , Adamts5 (Loreti and Sacco, 2022

It can be useful when the skin looks tired, dry, or uneven