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30 Role of the vascular wall components The endothelium senses mechanical and hormonal stimuli
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Strategies to minimize reactions include rotating injection sites consistently to avoid repeated trauma to the same area, ensuring the solution is at room temperature before injection (cold injections can increase irritation), injecting slowly rather than quickly, and using a smaller gauge needle for less tissue trauma
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Vitamin C directly inhibits tyrosinase activity (the enzyme involved in melanin synthesis) and neutralizes free radicals responsible for oxidative stress
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