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In clinical specimens, the endogenous levels of FBI-1 were positively associated with Glutathione Peroxidase 4 (GPX4) and negatively related with the expression of miR-324-3p

This process is accompanied by the ETC breakdown with the failure to produce the necessary amount of ATP, uncompensated production of ROS and RNS, and breakdown of various molecules, which leads to the loss of mitochondrial and cell integrity, and activation of programmed cell death and necrosis

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Am J Physiol Renal Physiol 314:F702f14 Kwon MY, Park E, Lee SJ, Chung SW (2015) Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

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