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A 6 to 12-week usage period followed by a 4 to 8-week break reflects the referenced clinical guidance available, according to a review published in Rupa Health

Doses above ~150 mg/day arent supported by current data

Patients using once-weekly semaglutide are advised to make lifestyle changes, including a reduced-calorie diet and increased physical activity, to improve the efficacy of the drug for optimal weight loss

doi: 10.1111/cns.13207 2

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