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The top-scoring compounds were then synthesised as described in the Chemistry supplementary information

Symptoms of B12 deficiency include exhaustion no matter how much you sleep, muscle weakness and frequent cramping, constipation, loss of appetite and unexplained weight loss, numbness or tingling in the hands and feet, depression, and problems with memory and focus

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Initially conceptualized as a therapeutic for neurodegenerative disorders such as Alzheimers and Parkinsons disease, its primary mechanism of action involves high-affinity binding to hepatocyte growth factor (HGF) and its cognate receptor c-Met

Therefore, elevated levels of immunoreactivity may be linked to structural abnormalities or genetic malformations of the X chromosome, such as monosomy