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However, beyond the primary endpoint, this study then became an open-label trial up to week 52

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The radiation exposure extends into the papillary layer of the dermis, influencing cellular elements within the dermis and the subcutaneous region, such as fibroblasts, endothelial cells of blood vessels, and Langerhans cells, and stimulates the activity of matrix metalloproteinases (MMPs), leading to the breakdown of collagen and elastin fibers, which causes visible photoaging damage such as skin relaxation, sagging, and abnormal increase of wrinkles [6]