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In in vitro cell experiments using 3T3L1 preadipocytes as a model, treatment with NNMTi significantly reduced preadipocyte differentiation efficiency and markedly downregulated the expression of adipocyte markers (such as PPAR and C/EBP) in a dosedependent manner
Experimental findings also suggest that NNMT inhibition may enhance stem cell activity and support regenerative responses in skeletal muscle tissue, making it a compound of interest in ongoing biochemical and metabolic research