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Ann Surg Oncol (2015) 22(9):296571

Oxidative stress, exercise, and antioxidant supplementation

These can include a combination of injections, oral supplements, and topical treatments to achieve and maintain the desired skin tone

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321,336 Altered phosphorylation of insulin receptor substrate proteins, particularly IRS-1 and IRS-2, is implicated in neuronal insulin resistance, 20,337 which impairs insulins neurotrophic effects, leading to reduced neurite outgrowth and increased vulnerability to injury