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Some studies suggest that doses of 1,200mg to 1,800mg daily might offer benefits, but these higher amounts also increase the risk of side effects

Mayo, J

E.TurgemanG

C., Chen, F., Che, X

Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer