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In cases of deficiency: anaemia, digestive, neurological and psychological disorders Anaemia, characterized by insufficient iron in the blood, occurs frequently in people with a vitamin B12 deficiency

Glutathiones redox activity is essential for preventing damage to DNA, proteins and cell membranes that can accelerate cellular aging

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DOI 10.1001/jama.2021.3224 - run-in nausea 47% falling to 14% at maintenance

Lastly, some biomarkers discussed in this review are still under investigation and lack validation in large, diverse cohorts, which limits their immediate clinical applicability