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After decades with no disease-modifying drug, 20242026 finally delivered the first targeted therapies: Novartis ianalumab met both NEPTUNUS-1 & NEPTUNUS-2 Phase 3 endpoints and won FDA Breakthrough Therapy status in Jan 2026, and J&Js nipocalimab was positive in the Phase 2 DAHLIAS trial ( The Lancet )

There was no evidence for nonlinearity in the metabolism of trimethylamine to trimethylamine-N-oxide

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The MBC of all MRAB isolates are similar 1516 g/ml

Non-histone lactylation can influence the spatial localization, conformation, and other characteristics of target proteins, thereby regulating the stability of proteinprotein interactions and ultimately altering their functional state

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