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LDHB KD significantly downregulated GSH synthesis genes, such as glutamate-cysteine ligase (GCL) catalytic and modifier subunits (GCLC and GCLM), GSH synthetase (GSS), and GSH reductase (GSR), as well as the GSH gene signature ( Figure 1f

Methylation is the addition of a methyl group (a carbon surrounded by hydrogen atoms) to a substrate and it occurs in the body a billion times per second

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PMCID: PMC4435046