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The study also included a catalytically inactive C145A M pro mutant (lacking the active site cysteine), which was also used as a bait protein, in order to discriminate false positives that might bind non-specifically to the M pro active site cysteine via disulfide bond formation

2011 Oct;211(1):99-106

Zeng, H., Hamlin, S

A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease

Headaches on tirzepatide tend to be most common in the first month and often relate to dehydration or caloric adjustment

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