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The most consistent finding: researchers who dose MOTS-c in the morning during fasted states report more pronounced shifts in substrate utilizationmeasured via respiratory exchange ratio (RER)than those administering it post-meal

Research has examined NNMT inhibition as a potential intervention point in metabolic biology, with particular interest in adipose tissue, where NNMT expression is elevated in some obesity models

Others experience gradual benefits over several weeks of consistent use

They produce enough in their digestive systems via bacterial fermentation