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CD47 the surface protein CD47 is a receptor that binds to signal-regulatory protein alpha (SIRP) or thrombospondin-1 (TSP-1) and acts as a signal to inactivate the phagocytosis in macrophages

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Instead, its effects appear to be highly localized and systemic, promoting a cascade of healing processes

The interplay of microbiota, immune system, nervous system neurotransmitter synthesis, and neuroplasticity transitions is also widely studied

This is a stressor for the body, causing hypoxia of intestinal cells due to redistribution of blood in the body, hyperthermia and dehydration [158, 159]

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