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These modifications collectively address the major limitations of natural amylin - its tendency to aggregate into toxic fibrils, rapid degradation, and poor pharmacokinetic properties - while preserving and enhancing its beneficial metabolic effects

Dysregulation of HRG1 can lead to heme accumulation and pathologies associated with impaired recycling [17]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Wise L.A., Radin R.G., Palmer J.R., Kumanyika S.K., Boggs D.A., Rosenberg L

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