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Mice were fed with either an unsupplemented diet or a diet supplemented with 2% creatine or 1% CoQ 10 or a combination of these two for one week before being implanted subcutaneously with osmotic minipumps filled with MPTP 170mg/ml in PBS that delivered MPTP at a dose of 40mg/kg body weight daily for 28 day

May be repeated daily, if indicated