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Figure 1 Furthermore, SAM serves as a methyl donor, methylating DNA and proteins, including histones (Zade et al., 2023), which in turn influences epigenetic regulation, and gene expression ( Figure 1 )

B 12r and B 12s can be prepared from cyanocobalamin by controlled potential reduction, or chemical reduction using sodium borohydride in alkaline solution, zinc in acetic acid, or by the action of thiols

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We express our gratitude to Pengfei Gong, Ruipei Ouyang, and Yongjie Shi from Jiangsu Province Engineering Research Center of Synthetic Peptide Drug Discovery and Evaluation, China Pharmaceutical University , for helping revise the manuscript

Lead interaction with human protamine (HP2) as a mechanism of male reproductive toxicity

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