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Oxidative stress Oxidative stress is a pivotal mechanism behind ECD [99, 100], consisting of an imbalance of the redox state due to reactive oxygen species (ROS) overproduction, antioxidant systems depletion, or both
82474105), Sichuan Provincial Natural Science Foundation Project (Nos 2024NSFSC0049, 2025ZNSFSC0581), Sichuan Science and Technology Program (No
Whilst loss of the normal SOD1 antioxidant enzymatic activity was initially proposed as a cause of neurodegeneration, further research implicated gain of a toxic function instead (Hu et al., 2003)