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The unfortunate truth is that big risk signals (lets say the kind you get from drinking antifreeze) can be spotted from the anecdotal experience of people in the world just trying things, but small-but-serious risk signals (lets say cardiovascular disease with tofacitinib) are really hard to identify without a proper trial or a proper observational study

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218 Conceptually, astrocytes (similarly to microglia) express several major phagocytic receptors allowing them to identify dead or dying cells and debris

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