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Community-reported effects (nausea, GI discomfort, headache) come only from anecdotal vendor/forum sources, not controlled studies

Therapy for a severe deficiency: 1000g Supply vs Intake: Not all Vitamin B12 can be Absorbed These rather high dosages are explained through the biological mechanism that enables the body to intake vitamin B12

Yet even more effective is its role as an opponent of free radicals and its effect in combatting nitrosative stress an underestimated and possibly central element in the development of many diseases

B12 supports this process by promoting red blood cell production, which ensures oxygen delivery to tissues and facilitates nutrient absorption

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However, it remains largely experimental