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PMCID: PMC9641984
Nevertheless, the combinatorial treatment with tamoxifen and antioxidants could promote anti-cancer efficacy of tamoxifen as was demonstrated in the model of DMBA-induced mammary carcinogenesis in SpragueDawley rats in which an administration of tamoxifen in combination with riboflavin, niacin, and coenzyme Q10 restored lipid peroxide level and the activity of anti-oxidants accompanied by enhanced antitumor activity [110]
In rectal cancer chemoradiotherapy and metastatic renal cell carcinoma combinations, CRLX101 has produced signals consistent with vascular normalization and radiosensitization, although randomized trials have so far shown mixed results for hard outcomes such as progression-free survival [91, 92]
Energy Metabolism Signaling: Investigated for downstream effects on NAD availability and mitochondrial efficiency
While we cannot fully exclude contributions from bacterial number, we primarily used the reporter to infer bacterial metabolic activity and energy state
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