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Neurotrophic factor receptors supporting neuronal survival Trk receptor family: TrkA binds nerve growth factor (NGF), TrkB binds brain-derived neurotrophic factor (BDNF), TrkC binds neurotrophin-3 (NT-3)

A 2025 meta-analysis of 7 RCTs (n=456) reported standardized mean differences of -0.72 for wrinkles (95% CI -1.02 to -0.42

Many medical experts, including career FDA scientists, say there isn't enough data and research to prove the peptides are safe and effective, warning of possible quality control problems, contamination risks, and the potential for dangerous allergic reactions

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Tertiary source

Petrov Research Institute of Oncology in St