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A general finding is that obese patients fulfilling criteria for MetS together with low IGF-1 plasma levels tend to develop a worse cardiovascular disease outcome than those with mid-normal to high-normal IGF-1 levels [213]

doi: 10.1038/s41598-025-92868-y 74 PereiraAGEchaveJJorgeAOSNogueira-MarquesRNur YuksekEBarcielaPet al

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pointed out that renal hypoxia contributes to heightened T cell infiltration and kidney damage, partially mediated by HIF-1-induced metabolic reprogramming in lupus-prone mice (MRL/lpr mice)

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