Research protocols often recommend refrigeration after reconstitution and limited use windows (e.g., 728 days depending on the compound)
For example, most studies report that NCs are present in skeletally mature non-chondrodystrophic dogs, pigs, ferrets, rabbits, rats, and mice [4, 5, 8, 41], whereas in chondrodystrophic dogs, goats, horses, cows, and sheep, they disappear before skeletal maturity is reached [4, 5, 8, 80]
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The only minor side effects have been cramping, bloating, and lower zinc levels in people who used glutathione over long periods