In diabetic wound models, GHK-Cu treatment resulted in higher levels of these protective molecules along with increased activation of antioxidant enzymes
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In hindlimb ischemia models, the peptide accelerates blood flow recovery as measured by laser Doppler scanning, with histological analysis confirming increased vessel numbers and enhanced vascular expression of VEGFR2
As predicted in silico, the addition of relatively small, lipophilic groups to the meta position of the ring maintained or slightly improved affinity when measured by the R2KD assay (Table 2)
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