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Ligand binding activates adenylyl cyclase, elevating intracellular cAMP and triggering PKA-mediated phosphorylation of downstream steroidogenic targets including CYP11A1, CYP17A1, and 3-HSD

Miller, Wilbur R

Altissimi G, Salviati M, Turchetta R, et al

qRT-PCR analysis revealed the marked upregulation of CDKN2A (encoding p16) , CDKN1A (encoding p21) , interleukin-8 ( IL-8) , and matrix metalloproteinase ( MMP)-12 expression (Figure 1D)

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AOD-9604 10mg is the preferred format for established research programmes with higher throughput requirements, dose-response studies, multi-arm experiments comparing several concentration levels, or extended research programmes requiring multiple experimental runs