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Early impairment of NGF/TrkA signaling in AD can lead to reduced synaptic vesicle secretion and decreased presynaptic protein expression, resulting in presynaptic functional impairment of cholinergic primary neurons [88]
By interrupting cytokine synthesis and cytokine processing, caudatin interrupts both upstream signaling pathways and downstream effector mechanisms of mast cell-mediated inflammation, which favors its characterization as a therapeutic candidate for pathologies in which excessive inflammatory responses occur, such as in the case of severe acute respiratory distress syndrome due to COVID-19 (Figure 3A)
Pharmacological targeting of CSF1R inhibits microglial proliferation and aggravates the progression of cerebral ischemic pathology
They treat the two peptides as interchangeable cousins, list a few benefits for each, and leave patients with no useful framework for choosing between them