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We suspected that rec-ECM1 was either inefficiently delivered to the liver injury site or was rapidly cleared or interacted with other proteins in circulation

in tumors, ROS stabilize HIF-1 to promote angiogenesis (VEGF) and immune checkpoint molecule expression (e.g., PD-L1), shaping an immunosuppressive microenvironment 104,105

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Spontaneous iron overload in Sprague-Dawley rats

Proteins were visualized using the Supersignal West Pico Chemiluminescent Substrate system (Pierce, Fenton, MO) and molecular weights determined by comparison to protein ladders (BenchMark, Invitrogen

Journal of Gerentology, 2011